细胞力学进展

所属分类:力学  
出版时间:2011-5   出版时间:高等教育出版社   作者:李少凡 等主编   页数:284  

内容概要

《细胞力学进展》(英文版)从交叉学科的角度系统地介绍和总结了细胞力学和细胞物理研究领域的前沿课题和最新进展。其显著的特点是用分子力学和复杂连续介质力学的方法研究和计算细胞的演变和分化;将定量的数学力学分析方法与实验手段相结合来探讨细胞的生物物理特性。
《细胞力学进展》(英文版)适合作为从事分子生物学、生物工程和力学、软物质力学和物理、计算力学,以及生物化学和医学的科研人员和研究生的参考书。
《细胞力学进展》(英文版)的主编是美国加州大学伯克利分校的李少凡教授和南非科学院院士、开普半岛科技大学的孙博华教授。

书籍目录

Chapter 1  Modeling and Simulations of the Dynamics of Growing Cell
Clusters
1.1 Introduction
1.2 Single cell geometry and kinematics
1.2.1 The continuum model
1.2.2 The numerical model for the cell geometry
1.3 Single cell equilibrium and material model
1.3.1 Cell equilibrium
1.3.2 The material model
1.3.3 Determination of material constants
1.4 Modeling cell interactions
1.4.1 Cell-to-cell contact
1.4.2 Cell-to-cell adhesion
1.4.3 Cell-to-cell interaction test
1.5 Modeling the cell life cycle
1.6 Details of the numerical implementation
1.6.1 The finite element model
1.6.2 Contact/adhesion interface detection
1.6.3 Time integration
1.6.4 Parallelization
1.7 Numerical results
1.8 Summary and conclusions
References
Chapter 2 Multiscale Biomechanical Modeling of Stem
Cell-Extracellular Matrix Interactions
2.1 Introduction
2.2 Cell and ECM modeling
2.2.1 Basic hypothesis and assumptions
2.2.2 Hyperelastic model
2.2.3 Liquid crystal model
2.3 Contact and adhesion models for cell-substrate
interactions
2.3.1 The adhesive body force with continuum mechanics contact
2.3.2 The cohesive contact model
2.4 Meshfree Galerkin formulation and the computational
algorithm
2.5 Numerical simulations
2.5.1 Validation of the material rhodels
2.5.2 Cell response in four different stiffness substrates
2.5.3 Cell response to a stiffness-varying substrate
2.5.4 Comparison of two different contact algorithms
2.5.5 Three-dimensional simulation of cell spreading
2.6 Discussion and conclusions
References
Chapter 3 Modeling of Proteins and Their Interactions with Solvent
3.1 Introduction
3.2 Classical molecular dynamics
3.2.1 Coarse-grained model
3.2.2 High performance computing
3.3 Principal component analysis
3.3.1 Three oscillators system analysis with PCA
3.3.2 Quasi-harmonic analysis
3.3.3 Equilibrium conformational analysis
3.4 Methods and procedures
3.4.1 Framework
3.4.2 Overlap coefficients
3.4.3 Correlation analysis
3.4.4 PCA with MD simulation
3.4.5 Kabsch algorithm
3.4.6 Positional correlation matrix
3.4.7 Cluster analysis
3.5 MD simulation with T4 lysozyme
3.5.1 Equilibration measures
3.5.2 Fluctuation analysis
3.5.3 Mode selection and evaluation
3.5.4 Eigenvalue analysis
3.5.5 Overlap evaluation
3.5.6 Identification of slow conformational flexibility
3.5.7 Correlation analysis of T4 lysozyme
3.6 Hemoglobin and sickle cell anemia
3.6.1 Molecular dynamic simulation with NAMD
3.6.2 Conformational change analysis
3.6.3 PCA analysis
3.6.4 Correlation analysis with HbS interaction
3.7 Conclusion
References
Chapter 4 Structural, Mechanical and Functional Properties of
Intermediate Filaments from the Atomistic to the Cellular Scales
4.1 Introduction
4.1.1 Hierarchical structure of vimentin intermediate
filaments
4.1.2 The structural and physiological character of keratin
4.2 Connecting filaments to cells level function and pathology
4.2.1 Bending and stretching properties of IFs in cells
4.2.2 IFs responding differently to tensile and shear stresses
4.2.3 Mechanotransduction through the intermediate filament
network
4.3 Experimental mechanics
4.3.1 Single filament mechanics
4.3.2 Rheology of IF networks in vitro
4.3.3 IF networks rheology in cells
4.4 Case studies
4.4.1 Single vimentin filament mechanics
4.4.2 Network mechanics
4.4.3 The mechanical role of intermediate filament in cellular
system
4.5 Conclusion
References
Chapter 5 Cytoskeletal Mechanics and Rheology
5.1 Introduction
5.2 Modelling semiflexible filament dynamics
5.3 Experimental measurements
5.3.1 Glass microneedles
5.3.2 Cell poking
5.3.3 Atomic force microscopy
5.3.4 Micropipette aspiration
5.3.5 Microplates
5.3.6 Parallel-plate flow chambers
5.3.7 Optical tweezers
5.3.8 Magnetic traps
5.4 Computational models
5.5 Conclusion
References
Chapter 6 On the Application of Multiphasic Theories to the
Problem of Cell-substrate Mechanical Interactions
6.1 Introduction
6.2 The physics of contractile fibroblasts and their
interactions with an elastic substrate
6.2.1 Cell spreading, contractility and substrate elasticity
6.2.2 Molecular mechanisms of cell contractility
6.3 Multiphasic mixture theory and cell contractility
6.3.1 The cytoplasm as a quadriphasic medium
6.3.2 Mass transport and mass exchange within the cell
6.3.3 Contractility and force balance
6.3.4 Model's prediction for simple cases
6.4 Interaction between contractile cells and compliant
substrates
6.4.1 Two-dimensional plane stress formulation
6.4.2 Numerical strategy: XFEM-level methods
6.4.3 Analysis of mechanical interactions between a
contractile cell and an elastic substrate
6.5 Summary and conclusion
6.5.1 Summary
6.5.2 Limitations of the multiphasic approach
6.5.3 Concluding remark
References
Chapter 7 Effect of Substrate Rigidity on the Growth of Nascent
Adhesion Sites
7.1 Introduction
7.2 Model
7.3 Results and Discussion
7.4 Conclusion
References
Chapter 8 Opto-Hydrodynamic Trapping for Multiaxial Single-Cell
Biomechanics
8.1 Introduction
8.2 Optical-hydrodynamic trapping.
8.2.1 Optical physics and microfluidics
8.2.2 Theoretical stress analysis
8.2.3 Experimental and computational flow validation
8.2.4 Applied stresses and strain response
8.2.5 Multiaxial single-cell biomechanics
8.3 Discussion
References
Chapter 9 Application of Nonlocal Shell Models to Microtubule
Buckling in Living Cells
9.1 Introduction
9.2 Nonlocal shell theories
9.2.1 Constitutive relations
9.2.2 Shear deformable shell model
9.2.3 Thin shell model
9.3 Bending buckling analysis
9.4 Numerical results and discussion
9.5 Conclusions
Appendix A
Appendix B
Appendix C
Appendix D
References

章节摘录

版权页:插图:In
this
method.the
fluid
flow
through
a
chamber
8urface
coated
with
a
cellmonolayer
iS
used
to
study
response
of
cells
to
fluid
flow;a
cellular
probe
iSused
to
measure
this
response.Several
cell
types
such
as
vascular
endothe-lial
cells
and
osteocytes
are
physiologically
exposed
to
fluid
flow
and
shearstress.Cells
sense
these
external
forces
and
react
accordingly;this
process
iscrucial
for
many
regulatory
processes.For
example,endothelial
surface
layerhas
multifaceted
physiological
functions
and
behaves
as
a
transport
barrier,as
a
porous
hydrodynamic
interface
in
the
motion
of
red
and
white
cells
inmicrovessels,and
as
a
mechanotransducer
of
fluid
shearing
stresses
to
theactin
cortical
cytoskeleton
of
the
endothelial
cell.Endothelial
cells
adoptan
elongated
shape
in
the
flow
direction
if
they
are
subjected
to
a
shear
flow.A
similar
situation
exists
for
osteocytes
in
bone
where
mechanosensing
con-trols
bone
repair
and
adaptive
restructuring
processes.It
iS
believed
thatstrain.derived
flow
of
interstitial
fluid
through
lacuno-canalicular
porositymechanically
activates
the
osteocytes.There
are
three
candidates
stimulat-ing
cells:wall
shear
stress.streaming
potentials.and
chemotransport.Controlling
the
wall
shear
stress
and
measuring
its
effect
on
fluid
transport.bone
cell
nitric
oxide,and
prostaglandin
production
can
be
used
to
study
thenature
of
the
flow-derived
cell
stimuli.Fluid
shear
stress
rate
iS
also
animportant
parameter
for
bone
cell
activation.

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