基因X

所属分类:生物科学  
出版时间:2010-1   出版时间:高等教育出版社   作者:Krebs   页数:930  
Tag标签:分子生物学,基因,生物,教材,MolecularBiology,Biology  

前言

  New data are acquired daily, and new insights into well-studied processes come on a scale measured in weeks or months rather than years. Its difficult to believe that the first complete organism genome sequence was obtained less than fifteen years ago. The structure and function of genes and genomes and their associated cellular processes are sometimes elegantly and deceptively simple but frequently amazingly complex, and no single book can do justice to the realities and diversities of natural genetic systems.  This book is aimed at advanced students in molecular genetics and molecular biology. In order to provide the most current understanding of the rapidly-changing subjects in molecular biology, we have enlisted twenty-one scientists to provide revisions and content updates in their individual fields of expertise. Their expert knowledge has been incorporated throughout the text. Much of the revision and reorganization of this edition follows that of the second edition of Lewiss Essential GENES, but there are many updates and features that are new to this book. Most notably, there are two new chapters: Chapter3 ("Methods in Molecular Biology and Genetic Engineering") provides an introduction to the concepts and practice of laboratory techniques in molecular biology early on in the book, and Chapter 8 ("Genome Evolution") combines, expands, and updates material that had been scattered among various chapters in previous editions, as well as introducing a number of topics new to this book. This edition is generally up dated and reorganized for a more logical flow of topics, and many chapters have been renamed to better indicate their contents. In particular, discussion of chromatin organization and nucleosome structure now precedes the discussion of eukaryotic transcription, because chromosome organization is critical to all DNA transactions in the cell, and current research in the field of transcriptional regulation is heavily biased toward the study of the role of chromatin in this process. The discussion of transcriptional activation and chromatin remodeling has accordingly been combined into one chapter (Chapter 28). Two chapters on transposons and retroposons have been combined into one (Chapter 17). In addition, some chapters have been revised to contain extensive new material. The original intro ductory chapter on messenger RNA has been entirely rewritten to cover more advanced topics (Chapter 22, "mRNA Stability and Localization"), and the regula tory RNA chapter has been dramatically expanded to include material on RNAi pathways (Chapter 30,"Regulatory RNA"). Many new figures are included in this book, some reflecting new developments in the field, particularly in the topics of chromatin structure and function, epigenetics, and regulation by noncoding and micro RNAS in eukaryotes.

内容概要

分子生物学与分子遗传学领域正经历着日新月异的变化,每天都会出现新的数据,那些热门的研究进程,过去每隔数年才会出现新的见解和看法,现在只要几周或几个月。在过去几十年里,对广大教学者来说,Lewin的《基因》是一本十分优秀的教材,该书对分子生物学和分子遗传学进行了精彩的论述,内容涵盖了基因的结构、序列、组织和表达。最新版的Lewin本书,拥有一支崭新的知识渊博的作者队伍,21位科学家根据各自的专业研究特长,对书中内容进行了修订和更新,以保证本书是本领域最新颖全面的教材。本书在内容上增加了一些新的章节,结构也进行了一些调整,使得全书各个主题在排列上更加富有逻辑性。另外许多章节也重新命名,和内容更加相符。新版中还包含了一些新的教学特色,便于学生在阅读本书过程中更好地学习;增加一个在线学习导航,学生可以使用它对关键内容进行自我测试。  新版特色  ·全新的第3章——分子生物学和基因工程方法,详细介绍了分子生物学实验技术的概念和实践。  ·新插入的第8章——基因组进化,对于早期版本分散在各章节中的相关材料做了整合、扩展和更新,并介绍了一些新进展。  ·第22章——mRNA的稳定性和定位,完全更新并重写,以包含更多的前沿内容。  ·第30章——调控RNA和小RNA,特别引入了RNAi通路的相关内容。  ·大量崭新的精美插图反映了相关领域的新进展,尤其是基闪组结构和功能、表观遗传学,以及原核生物中非编码和小RNA的调控。

书籍目录

ContentsPrefacePart
1.
GENES
AND
CHROMOSOMES
1 Chapter
1.
Genes
Are
DNA
2 Chapter
2.
  Genes
Code
for
Proteins
26  Edited
by
Esther
Siegfried,
Pennsylvania
State
University,
Altoona Chapter
3.
Methods
in
Molecular
Biology
andGenetic
Engineering
42Edited
by
John
Brunstein,
University
of
British
Columbia Chapter
4.
The
Interrupted
Gene
79Edited
by
Donald
Forsdyke,
Queens
University Chapter5.
The
Content
of
the
Genome
98 Chapter
6.
Genome
Sequences
and
GeneNumbers
118 Chapter
7.
Clusters
and
Repeats
139 Chapter
8.
Genome
Evolution
159 Chapter
9.
Chromosomes
189Edited
by
Hank
W.
Bass,
Florida
State
University Chapter
10.
Chromatin
220Part
2.
DNA
REPLICATIONAND
RECOMBINATION
262 Chapter
11.
The
Replicon
263Edited
by
Stephen
D.
Bell,
Oxford
University Chapter
12.
Extrachromosomal
Replicons
282Edited
by
Sgren
Johannes
Serensen
&
lars
Hestbjerg
Hansen,
University
of
Copenhagen Chapter
13.
Bacterial
Replication
Is
Connectedto
the
Ceil
Cycle
299Edited
by
Barbara
Funnell,
University
of
Toronto Chapter
14.
DNA
Replication
320Edited
by
Peter
Burgers,
Washington
University
Medical
School Chapter
15.
Homologous
and
Site-SpecificRecombination
348Edited
by
Hannah
L.
Klein
&
Samantha
Hoot,
New
York
University
Langone
Medical
Center Chapter
16.
Repair
Systems
391 Chapter
17.
Transposable
Elementsand
Retroviruses
419Edited
by
Damon
Lisch,
University
of
California,Berkeley Chapter
18.
Somatic
Recombination
andHypermutation
in
the
Immune
System
458Edited
by
Paolo
Casali,
Institute
for
Immunology,University
of
California,
IrvinePart
3.
TRANSCRIPTIONAN
D
POSTrRANSCRIPTIONALMECHANISMS
503 Chapter
19.
Prokaryotic
Transcription
504Edited
by
Richard
Gourse,
University
of
Wisconsin,
Madison Chapter
20.
Eukaryotic
Transcription
546 Chapter
21.
RNA
Splicing
and
Processing
573Edited
by
Xiang-Dong
Fu,
University
of
California,San
Diego,
School
of
Medicine Chapter
22.
mRNA
Stability
andLocalization
618Edited
by
Ellen
Baker,
University
of
Nevada,
Reno Chapter
23.
Catalytic
RNA
642Edited
by
Douglas
,7.
Briant,
University
of
Victoria Chapter
24.
Translation
665Edited
by
Cheryl
Keller
Capone,
Pennsylvania
State
University Chapter
25.
Using
the
Genetic
Code
704Edited
by
John
Perona,
University
of
California,
Santa
BarbaraPart
4.
GENE
REGULATION
734 Chapter
26.
The
Operon
735Edited
by
Liskin
Swint-Kruse,
University
of
Kansas
School
of
Medicine Chapter
27.
Phage
Strategies
767 Chapter28.Eukaryotic
TranscriptionRegutation
795 Chapter
29.
Epigenetic
Effects
AreInherited
828Edited
by
Trygve
ToUefsbol,
University
of
Alabama,
Birmingham Chapter
30.
Regutatory
RNA
861Gtossary
881Index
905

章节摘录

  Exons
act
as
modules
for
building
genes
thaiare
tried
out
in
the
course
of
evolution
in
various
combinations
(see
Section
4.9,
Some
ExonCan
Be
Equated
with
Protein
Functional
Domains)At
one
extreme,
an
individual
exon
from
onegene
may
be
copied
and
used
in
another
geneAt
the
other
extreme,
an
entire
gene,
includingboth
exons
and
introns,
may
be
duplicated.
Insuch
a
case,
mutations
can
accumulate
in
onecopy
without
elimination
by
natural
selectionas
long
as
the
other
copy
is
under
selection
tcremain
functional.
The
selectively
neutral
copymay
then
evolve
to
a
new
function,
becomeexpressed
at
a
different
time
or
in
a
differenlcell
type
from
the
first
copy,
or
become
a
nonfunctional
pseudogene.
FIGURE
8.19
summarizes
our
present
view
otthe
rates
at
which
these
processes
occur.  Thereis
a probability
that
a
given
gene
will
beincluded
in
a
duplication
in
a
period
of
onemillion
years.
After
the
gene
has
duplicated,differences
evolve
as
the
result
of
the
occurrence
of
different
mutations
in
each
copy.
Theseaccumulate
at
a
rate
of
-0.1%
per
million
years(see
Section
8.4,
A
Constant
Rate
of
Sequence
Divergence
Is
a
Molecular
Clock).
If
this
does
not
happen,
one
of
the
genes
is
likely
to
become
a
pseudogene
because
it
will
by
chance
gain
a
deleteri
ous
mutation,
and
there
will
be
no
puri
fying
selection
to
eliminate
this
copy
so
by
genetic
drift
the
mutant
version
may
increase
in
frequency
and
fix
in
the
species.  Typically
this
takes 4
mil
lion
years
for
globin
genes;
in
general,
the
time
to
fixation
of
a
neutral
mutant
depends
on
the
generation
time
and
the
effective
population
size,
with
genetic
drift
being
a
stronger
force
in
smaller
populations.
In
such
a
situation,
it
is
purely
a
matter
of
chance
which
of
the
two
copies
becomes
inactive.
(This
can
contribute
to
incompatibility
between
different
individuals,
and
ultimately
to
speciation,
if
different
copies
become
inactive
in
different
populations.)
Analysis
of
the
human
genome
sequenceshows
that
-5%
of
the
genome
comprisesduplications
of
identifiable
segments
rangingin
length
from
10
to
300
kb.
These
duplicationshave
arisen
relatively
recently;
that
is,
there
hasnot
been
sufficient
time
for
divergence
betweenthem
for
their
homology
to
become
obscured.They
include
a
proportional
share
(-6%)
of
theexpressed
exons,
which
shows
that
the
duplications
are
occurring
more
or
less
irrespectiveof
genetic
content.

编辑推荐

  《基因X》由教育部高等教育司推荐,是国外优秀生命科学教学用书。

图书封面

图书标签Tags

分子生物学,基因,生物,教材,MolecularBiology,Biology


    基因X下载



用户评论 (总计54条)

 
 

  •     很好很经典的一本书。虽然有人说基因十没有基因九系统和权威,但我觉得基因十将整本书划分成几大斑块,如基因复制与重组、转录和转录后调控机制等,让人在学习时能够更加系统的了解分子生物学各领域的基本情况。尤其让我这个刚涉足分子生物学领域的学生高兴的是基因十中专门有一章介绍分子生物学常用实验(如克隆、核酸检测、DNA测序、Blotting和基因敲除等)的基本原理。总之,这本书是分子生物学领域人士的必备参考书!
  •     分子生物学的“圣经”再升级,经典读物不用多说
  •     值得收藏,学习分子生物的朋友应作为工具书
  •     对于学生物的孩子来说,从基因VIII到基因X,一直都是仰视的著作吧~~~~书本的质量相当不错!值得购买!
  •     生物学的圣物啊~~~~
  •     学分子生物学必须要看的经典著作,英文原版,要努力啃下来,相信一定收获很多
  •     书真的很好,跟得上最新进展。
  •     超棒超喜欢!印刷精美~质量一流~纸张好 印刷好 内容更好!爽YY!
  •     本书的意义就不多说了,学生物的应该都知道。
    送来的书质量很好,铜版彩页,还挺重。
    全英文,需要慢慢研读。
  •     三百多元能买到跟原版几乎一样的书,很值,而且内容也确实不错。通读不现实,还是需要时查查比较好。
  •     比中国人写的的肯定要好,适合生物爱好者,另外心疼钱的话买之前先去图书馆看看有没有,我就是买了然后在图书馆发现GeneⅩ。。。。
  •     书挺厚的,虽然全英文可是也不难读懂,很不错,值得学生物的人人手一本.
  •     很好,相当不错的一本书
  •     送货速度很快,就是书皮有点小磨损,但没多大影响,当然,希望当当这方面能做得更好
  •     书比较好,买来了之后,但太厚了,看不完基本上
  •     发货很快,3天就从北京发到深圳。书的确很好,铜版纸印刷,很厚重,唯一的缺点就是,为啥不弄个硬壳的包装,否则怕很容易散架
  •     做自然科学的必备之书。
  •     适合专业人士人手一本
  •     书不错 就是有点沉
  •     A good reference book.
  •     perfect choice, perfect service!
  •     一本生物学转业的圣经,印刷精美,清晰!比原版低很多的价格,对得起这个价钱了!不过送货的速度太慢了。。。我等了一周左右才送到。
  •     经典图书,质量不错。就是有一个小疑问,是否附带光盘??
  •     印刷很精美的
  •     很好的一本书,生命科学必读。
  •     书页有点皱,不过不影响阅读,送货速度比较快。书的价格有点贵,不过确是一本好书。
  •     特价买的,主要是便宜
  •     国产书也就这样
  •     很满意 送货速度超级快
  •     学生物同学的好书啊
  •     基因VIII的最先修订本
  •     经典,不需要多说
  •     内容好,质量也可以。
  •     分子生物学的经典之作!
  •     适合入门者,对于学习生物和医学并从事这方面研究的人很有帮助。
  •     内容好,不太清楚内容
  •     这是本不错的书,书很好正版的
  •     但感觉这本书的用处也挺大的,书还可以
  •     这本书涉及到的生物学应用软件使用方法很多,有用的工具书。中科院指定参考书
  •     值得收藏,这本书很有用
  •     目前没发现不足,全面。。买书送国旗~
  •     特价买的,实验步骤非常清楚
  •     很好。,速度太慢了
  •     帮助不大,就是不怎么看的懂
  •     写的还是基本的知识,通俗易懂
  •     一般吧,考研要用的
  •     非常适合刚进实验室的研究生,是一本比较好的操作指南书籍。
  •     质量也可以。,经典著作
  •     考研用的,很不错的一本书
  •     内容讲解挺详细的,值得一看
  •     光盘竟然已经断成了两半!强烈不满!,方法讲述比较具体
  •     好厚哇,非常经典的一本教材。
  •     书是正版的,我喜欢
  •     对分子实验很有帮助,值得购买的好书
 

自然科学类PDF下载,生物科学PDF下载。 PPT下载网 

PPT下载网 @ 2017